Esketamine (SPRAVATO)

Esketamine (SPRAVATO)

Find relief from your depression in a safe and healing space.

ABOUT ESKETAMINE

Relief is within your reach.

Esketamine therapy is a treatment modality that uses a nasal spray to alleviate symptoms of Treatment Resistant Depression (TRD) and Major Depressive Disorder (MDD) with symptoms of acute suicidality. At NorCal Neurostimulation, we utilize SPRAVATO® in twice a week sessions.


Esketamine is not Ketamine. It is derived from the ketamine molecule but works a little bit differently.  Esketamine works by increasing glutamate receptors, which are abundant in the brain, allowing activation of more brain cells at once than traditional antidepressants. 


Esketamine has been reported to decrease suicidal thoughts and increase neurogenesis and neuroplasticity. The goal is to change patterns of maladaptive thinking. 

Meet our expert providers

Not sure if esketamine is right for you? Give us a call to discuss if you're a good candidate and to schedule an in-person consultation with one of our providers. 


Take the first step and complete our interest form below to connect with our esketamine coordinator.

What's involved

SPRAVATO is a prescription medication to be used alongside an oral antidepressant for best results. Patients self administer SPRAVATO nasal spray in-clinic and are monitored by staff for a two hour period of observation time. 


Esketamine has the potential to distort one's perception of the world around then while under the influence of the medication. This is why we administer in the clinic and monitor patients for two hours. 

Find Relief


Research studies show that FDA-approved Spravato treatment for depression is highly effective and rapid-acting.


Adults with treatment-resistant depression who were part of a clinical study were given either a nasal esketamine spray or a placebo spray.


Those who added esketamine, the active ingredient in SPRAVATO®, to their oral antidepressant experienced a greater reduction of depressive symptoms at four weeks compared to those who received placebo plus an oral antidepressant.


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